Knowledge, possession of information, mostly seems an entirely good thing. Knowing how to do things, understanding nature makes life easier.
Progress in knowlege gained has been rapidly increasing. Progress seems an entirely good thing, but the assymetry of offensive versus defensive capability and the difficulty to predict complex systems make the prospect that with continued progress it is only a question of time until anyone can create pathogens or weapons of mass destruction a serious concern and a leading contender for the solution to Fermi's paradox, i.e. the question why there do not seem to be any civilizations able to colonize other solar systems than the one where they emerged.
Bill Joy's influential call to contain dangerous technologies (robotic, genetic, nanotechnology) "Why the future doesn't need us" (re-)started many discussions on the risks of progress and what to do about it. The question whether the gathering of information, the accumulation of knowledge, is an intrinsically limited process is intriguing but it would be much more important to find creative solutions that offer different perspectives.